An infant child less than one year old died at a hospital in Chicago after testing positive for coronavirus.
The death is believed to be the first of an infant during the outbreak of the killer virus.
The incident was confirmed by the Illinois Department of Public Health which did not release further details of the tragedy.
“There has never before been a death associated with COVID-19 in an infant. A full investigation is underway to determine the cause of death,” said IDPH Director Dr. Ngozi Ezike.
“We must do everything we can to prevent the spread of this deadly virus. If not to protect ourselves, but to protect those around us.”
We’ll be bringing you the very latest updates, pictures and video on this breaking news story.
Illinois has reported a total of 3,491 cases, including 47 deaths, in 43 counties in the state.
The age of cases ranges from younger than one to 99 years.
In the United States, the number of cases stood at 119,327 on Saturday afternoon with at least 1,992 deaths.
The number of cases in the United States eclipsed those of China and Italy on Thursday.
Earlier today, Donald Trump said he was considering imposing a quarantine on New York, New Jersey and Connecticut.
Travel would be restricted to and from those states to help stop the spread of coronavirus which has infected 100,000 people in the US so far.
“We’d like to see New York quarantined because it’s a hotspot — New York, New Jersey, maybe one or two other places, certain parts of Connecticut quarantined. I’m thinking about that right now,’ he said today.
“We might not have to do it but there’s a possibility that sometime today we’ll do a quarantine — short term two weeks for New York, probably New Jersey and parts of Connecticut.”
Asked whether he thought the United States would open by Easter Sunday, Trump said at the White House, “We’ll see, what happens,” he said.